Tens of millions of people are "in chains" because of human trafficking and forced labor, and it leading to their "dehumanization and humiliation," the pope said.
God reveals himself to humble and meek hearts, said Pope Francis at morning Mass.
"Many can know science, theology as well. But if they do not do this theology on their knees, that is, humbly, like the little ones, they will not understand anything. They will tell us many things, but they will not understand anything," he said Dec. 2 in his homily during the Mass in the Domus Sanctae Marthae where he lives.
Francis said the church must be bold in recognizing and changing "the structures that give us a false sense of protection and that condition the dynamism of charity."
Believing in eternity and in the final establishment of the kingdom of God, Christians throughout history -- starting with the disciples -- were filled with questions such as when the end will come and what will happen to the created world, Pope Francis said.
No one knows the answer to those questions, the pope said Wednesday at his weekly general audience, but Catholics are convinced that the end of time will not bring the "annihilation of the cosmos and of everything around us."
Almost every papal trip abroad is a complex mix of the religious and political, and that will be especially true of Pope Francis' Nov. 28-30 visit to Turkey.
Using a newly simplified rite, Pope Francis proclaimed six new saints and praised them for the love and self-giving with which they served God and built up his kingdom by serving the poor and needy.
Creating the two Indian and four Italian saints Sunday, the feast of Christ the King, the pope said, "They responded with extraordinary creativity to the commandment of love of God and neighbor," dedicating themselves, "without holding back, to serving the least and assisting the destitute, sick, elderly and pilgrims."
The appointment fills what had been an unusually long vacancy among the Vatican's highest offices and elevates Sarah to the most senior African prelate in the church's governance.
Pope Francis called for greater acceptance of people with autism spectrum disorders and their families to break down the "isolation" and "stigma" that burdens them.
"Everyone should be committed to promoting acceptance, encounter and solidarity through concrete support and by encouraging renewed hope," the pope said Saturday during a meeting with people with autism disorders and their families, and with 700 participants in a three-day conference on autism and related disorders, organized by the Pontifical Council for Health Care Ministry.
Like many Catholic parishes, the Vatican has turned to a raffle to raise money; the difference is, though, the prizes are items originally given as gifts to Pope Francis.
For 10 euros -- about $12.50 -- anyone can go to the Vatican post office or pharmacy and buy a chance to win a Fiat Panda 4x4, a small SUV "fully loaded" with every option available, the Vatican said. Tickets are not for sale on the Internet or anywhere outside Vatican City.
"These are matters that affect all families ... We want to focus next year not just on the neuralgic sexual issues that seem to dominate the American media."